Rat Corticotropin-Releasing Hormone Gene: Sequence and Tissue-Specific Expression*
نویسندگان
چکیده
منابع مشابه
Steroid hormone mediated regulation of corticotropin-releasing hormone gene expression.
Corticotropin-releasing hormone (CRH), a 41 amino acid polypeptide, is expressed in many regions of central nervous system and peripheral tissues and mediates many physiological functions. Abnormal production of CRH is involved in some pathological processes. Among various endogenous factors that modulate CRH production, steroid hormones control CRH production by regulating its gene transcripti...
متن کاملNucleotide sequence and expression of the mouse corticotropin-releasing hormone gene.
The mouse corticotropin-releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human, rat, and ovine genes with two exons and an intervening sequence of 675 base pairs interrupting the 5' untranslated sequence of the mature mRNA. Analysis of the nucleotide sequence reveals that the mouse CRH p...
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The GHRH receptor is expressed in the somatotroph cell of the anterior pituitary, where it functions to mediate GHRH-stimulated GH release. To study pituitary and somatotroph cell-specific expression of this gene, a transgenic mouse model and complementary cell culture experiments were developed. The activity of the 1.6-kb proximal rat GHRH receptor promoter was examined in vivo by generating t...
متن کاملCorticotropin-releasing hormone physiology
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
متن کاملCorticotropin-releasing hormone receptors.
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1987
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend-1-5-363